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Cosmetic safety assessment · EN / 中文

One source. Two languages. Every figure cited.

Exposure models and toxicological ingredient dossiers for cosmetic safety assessment — written in English and Chinese from the same underlying record, with every parameter traced back to its source.

Specimen · one entry from the exposure model compendium Leave-on · face
Face cream
面霜
Parameter
English
中文
Product category
Leave-on, applied to the face
驻留类,面部使用
Amount applied
1.54 g/dayidentical in both
Retention factor
1.00identical in both
Body weight
60 kgidentical in both
Relative daily exposure
24.14 mg/kg bw/dayidentical in both
Basis
P90 of measured consumption from European probabilistic survey data
基于欧盟概率法消费量调查数据的P90值
How it is used
Multiply by ingredient concentration and dermal absorption to obtain the systemic exposure dose (SED), then divide the point of departure by it for the margin of safety.
乘以原料浓度与经皮吸收率,得出全身暴露量(SED);再以起点剂量除以该值,即为安全边际(MoS)。
Source: SCCS Notes of Guidance, 12th revision (SCCS/1647/22). The compendium gives the equivalent entry under China's Technical Guidelines for Cosmetic Safety Assessment (2021) alongside, so the two frameworks can be compared directly.

Services

Three things, bought separately

Nothing here is a bundle. Take whichever piece you're missing.

Reference document

Exposure model compendium

Every cosmetic product type with its exposure parameters and worked model, under both the EU and Chinese frameworks, in English and Chinese. A desk reference — no formulation required, nothing to brief in.

£249one-off · immediate download
Per ingredient

Toxicological ingredient dossiers

A full endpoint review for one ingredient — identifiers in four INCI systems, regulatory status, every toxicological endpoint with its guideline and citation, and a point of departure with the reasoning for choosing it.

£395per ingredient · five working days
Quoted

Technical sections for safety assessments

The exposure and toxicological parts of a safety assessment, written to slot into the report your Responsible Person or filing agent assembles. We write the science; the submission stays with you.

On enquiryscope depends on the product

Compendium

What the compendium covers

Written once, kept current, and the same document for every reader — so two assessors working on the same product start from the same numbers.

Every product category

Leave-on and rinse-off, face, body, hair, oral and eye area — each with its amount applied, retention factor and relative daily exposure.

Both regulatory frameworks

EU values from the SCCS Notes of Guidance, and Chinese values from the 2021 Technical Guidelines, side by side rather than in two separate documents.

Worked calculations

A full systemic exposure dose and margin of safety worked through for each category, so the model can be checked rather than taken on trust.

Sourced to the clause

Every figure carries its citation and revision, so you can defend it to a reviewer without going back to the primary document.

Where the two diverge

Categories where the EU and Chinese parameters differ are flagged, with a note on which to use for which market.

Updated when guidance changes

Revisions are dated and superseded values are kept visible, so an assessment written last year can still be read against the version it used.

Dossiers

What an ingredient dossier contains

Commissioned per ingredient. Below is a fragment of one.

Phenoxyethanol
苯氧乙醇
Field
English
中文
CAS number
122-99-6identical in both
Regulatory control
Restricted — Regulation (EC) 1223/2009, Annex V/29. Maximum 1.0% in ready-for-use preparations.
受限 —(EC)1223/2009法规附录V/29。即用型制剂中最高限量1.0%。
Point of departure
357 mg/kg bw/day — 90-day dermal NOAEL of 500, adjusted 5/7 for dosing frequency.
357 mg/kg bw/day — 90天经皮NOAEL为500,按给药频率5/7校正。
Margin of safety
5,250 at 0.5% in a leave-on product — acceptable, threshold 100
5,250 驻留类产品中0.5%用量 — 合格,判定阈值100
Sources: SCCS/1575/16 Opinion on Phenoxyethanol · CIR Final Report 1990 · ECHA registration dossier.

Dossiers and assessments are prepared by a toxicologist registered with the UK Register of Toxicologists (UKRT) and the European Register of Toxicologists (ERT).

Scope

What we do, and what we don't

Worth knowing before you write, so nobody's time gets wasted.

We do

  • Bilingual exposure models by product category
  • Bilingual toxicological ingredient dossiers
  • Point of departure selection and justification
  • Exposure and toxicological sections for safety assessments
  • Annex II–VI checks against an ingredient list

We don't

  • Sign or issue the finished safety assessment
  • Act as your Responsible Person
  • Filing or registration submissions
  • Laboratory, stability or challenge testing
  • Label artwork or claims review

Enquire

Tell us what you need

We reply with a price and a date, usually the same working day.

Names only. Please don't send formulation percentages at this stage — we don't need them to quote, and we'd rather they stayed with you until there's an agreement in place.

We use what you send only to prepare a quote. It is not shared, and it is deleted if you don't proceed. A mutual NDA is available on request before any formulation detail changes hands.

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